Protein Folding is a Major Problem for Evolution
Frequently, discussions about protein folding launch straight into the subject. Sure, it is important, but what does it mean? Do proteins actually fold? That is the best way to describe what is happening.
Consider a weak analogy with origami. (Although this paper folding art is associated with Japan, other cultures seem to have developed it independently.) Paper of the correct dimensions is needed to fold into a recognizable shape, and the folding must be done correctly or the result is a wasted piece of paper.
Origami tsuru (crane), RGBStock / Manoel Silva |
All living things have proteins in their cells, each made up of a long chain of amino acids in a particular sequence. This sequence is specified by the DNA ‘instructions’ for making it. This chain is then folded to enable it to perform its particular function, using previously folded proteins called chaperonins. . . .Individual amino acids must bond with certain other amino acids at various parts of the chain in particular ways during the stages of folding. The task is astronomically difficult and incredibly complex—yet cells can do it in less than the blink of an eye. Cells also need to quickly unfold the protein chains, too.
You can read the rest at "Fast folding cells perform a truly amazing feat … and have from the beginning." Or you could print it out and read it. Then trim and fold it into a rabbit.